Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does exposure to rubella virus generate endocrine autoimmunity?

H J Bodansky1, B M Dean, P J Grant

  • 1Professorial Medical Unit, General Infirmary, Leeds, UK.

Diabetic Medicine : a Journal of the British Diabetic Association
|August 1, 1990
PubMed
Summary

Rubella vaccination did not trigger widespread endocrine autoimmunity in girls. While some islet cell antibodies appeared post-vaccination, they were transient, suggesting rubella

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic ketamine use associated with progressive multisystem organ dysfunction.

BMJ case reports·2026
Same author

Estimation of jaw-opening forces in adults.

Orthodontics & craniofacial research·2017
Same author

Mortality and acute complications in children and young adults diagnosed with Type 1 diabetes in Yorkshire, UK: a cohort study.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Diabetic hepatosclerosis: another diabetes microvascular complication?

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

Hypotheses on genetic contributions to the aetiology of diabetes mellitus.

Immunology today·2014
Same author

Epithelial MHC class II sub-region expression in autoimmunity.

Immunology today·2014

Area of Science:

  • Immunology
  • Endocrinology
  • Virology

Background:

  • Rubella virus is implicated as a potential trigger for autoimmune diseases like Type 1 diabetes.
  • Investigating the link between viral infections and the onset of autoimmunity is crucial for understanding disease pathogenesis.

Purpose of the Study:

  • To determine if rubella vaccination induces autoantibody responses against pancreatic islet cells and other endocrine tissues.
  • To assess the impact of live attenuated rubella vaccine on autoantibody prevalence in young girls.

Main Methods:

  • Autoantibody responses were measured in 239 10-year-old girls before and after rubella vaccination.
  • Islet cell antibodies (ICA), IgG-insulin autoantibodies, and thyroid antibodies were quantified.
  • Prevalence and changes in antibody levels were analyzed in relation to vaccination status.

Related Experiment Videos

Main Results:

  • Islet cell antibodies (ICA) were present in 2.9% before vaccination and appeared in 4.2% post-vaccination, but were low and transient.
  • Prevalence of IgG-insulin autoantibodies decreased after vaccination.
  • No new cases of thyroid antibodies were detected post-vaccination.

Conclusions:

  • Rubella vaccination did not induce significant or lasting endocrine autoantibody production in the studied cohort.
  • The role of viral infections, including rubella, in triggering endocrine autoimmunity in susceptible individuals remains an area for further research.