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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: Jun 3, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Do cilia put brakes on the cell cycle?

Peter K Jackson

    Nature Cell Biology
    |April 5, 2011
    PubMed
    Summary

    Dynein-binding proteins regulate cell cycle progression by affecting cilia length. These proteins, including Nde1 and Tctex1, influence the G1-S transition, impacting cell proliferation and differentiation.

    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Developmental Biology

    Background:

    • The cell cycle's G1-S transition is crucial for cell proliferation.
    • Cilia play roles in cellular signaling and development.
    • Dynein, a motor protein, is involved in intracellular transport and ciliogenesis.

    Discussion:

    • Two studies reveal that dynein-binding proteins modulate the G1-S cell cycle transition via ciliary regulation.
    • Nde1, a dynein light chain LC8 partner, affects ciliary length in vitro and in vivo, influencing G1-S progression.
    • Phosphorylated Tctex1, another dynein light chain, alters cilia length and accelerates G1-S, impacting neocortical development.

    Key Insights:

    • Dynein-binding proteins are novel regulators of the G1-S cell cycle checkpoint.

    More Related Videos

    Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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    Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

    Published on: September 26, 2025

    Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
    08:33

    Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

    Published on: December 5, 2017

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    Last Updated: Jun 3, 2026

    Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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    Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

    Published on: June 6, 2017

    Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
    08:13

    Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

    Published on: September 26, 2025

    Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
    08:33

    Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

    Published on: December 5, 2017

  • Cilia length modulation by dynein-binding proteins is a key mechanism for cell cycle control.
  • These findings link ciliopathies to cell cycle dysregulation and developmental processes.

    • Outlook:

    • Further research into dynein-binding proteins and cilia could reveal new therapeutic targets for cell cycle disorders.
    • Investigating the precise molecular mechanisms linking cilia length to G1-S progression is warranted.
    • Exploring the role of these proteins in other developmental contexts may uncover broader implications.