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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients

Juan José Díez1, Maurizio Bossola, María José Fernández-Reyes

  • 1Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid. jdiez.hrc@salud.madrid.org

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|April 5, 2011
PubMed

Insights

Serum leptin and leptin/body mass index (BMI) ratio do not predict cardiovascular disease (CVD) or mortality in hemodialysis patients. These markers are not associated with prevalent CVD or death risk in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) is a major concern in hemodialysis (HD) patients.
  • Leptin, a hormone involved in metabolism, has been investigated for its role in CVD.
  • The leptin/body mass index (BMI) ratio is a proposed marker for metabolic health.

Purpose of the Study:

  • To investigate the association between serum leptin and the leptin/BMI ratio with prevalent CVD in HD patients.
  • To determine the influence of these markers on all-cause and CVD-related mortality in HD patients.

Main Methods:

  • A cohort of 118 stable HD patients was studied.
  • Baseline serum leptin concentrations were measured.
  • Survival analysis and Cox regression were used to assess relationships with mortality.

Main Results:

  • The leptin/BMI ratio was similar in patients with and without CVD at baseline.
  • No independent association was found between the leptin/BMI ratio and prevalent CVD.
  • No significant relationships were observed between leptin levels or leptin/BMI ratio and all-cause or CVD-related mortality.

Conclusions:

  • Serum leptin concentrations and the leptin/BMI ratio are not associated with prevalent CVD in stable HD patients.
  • The leptin/BMI ratio does not appear to be a risk factor for mortality in this patient group.
Abstract

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