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Recombinant Adenovirus (AdV) Type 3 and Type 14 Isolated From a Fatal Case of Pneumonia

Diane C Halstead1, Gregory C Gray, Kenneth S Meyer

  • 1Jacksonville Pathology Consultants, P.A./Baptist Health Infectious Disease Laboratories, Jacksonville, Florida.

Reviews in Medical Microbiology : a Journal of the Pathological Society of Great Britain and Ireland
|April 5, 2011
PubMed

Insights

A fatal pneumonia case in a traveler returning from Iraq was linked to a novel adenovirus (AdV) recombinant. Genetic analysis identified a unique AdV3 and AdV14 hybrid, suggesting a new viral strain emerged.

Area of Science:

  • Infectious Diseases
  • Virology
  • Molecular Biology

Background:

  • Adenovirus infections can cause severe respiratory illness, particularly in immunocompromised individuals or travelers.
  • Recent travel history is crucial for identifying potential exposure to novel or endemic pathogens.
  • Coinfections with multiple viral strains can complicate diagnosis and treatment.

Purpose of the Study:

  • To report a fatal case of pneumonia potentially caused by adenovirus infection.
  • To characterize the specific adenovirus strain identified in the patient.
  • To determine if the observed viral characteristics represent a coinfection or a recombinant virus.

Main Methods:

  • Sequence analysis was performed to identify the adenovirus types.
  • Restriction analysis (REA) was utilized to differentiate between coinfection and recombination.
  • Clinical data and patient history were reviewed.

Main Results:

  • The patient, a 53-year-old male, presented with fatal pneumonia after returning from Iraq.
  • Sequence analysis identified both adenovirus type 3 (AdV3) and adenovirus type 14 (AdV14).
  • Restriction analysis indicated the presence of a single recombinant adenovirus with properties of both AdV3 and AdV14, not a coinfection.

Conclusions:

  • A fatal case of pneumonia was associated with a unique adenovirus recombinant.
  • This recombinant adenovirus, a hybrid of AdV3 and AdV14, represents a potentially novel viral entity.
  • Further investigation into the emergence and pathogenicity of adenovirus recombinants is warranted.

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