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Updated: Aug 24, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Isolated dehydroepiandrosterone sulphate hypersecretion: a case report
G Radetti1, E Cacciari, M Zachmann
1Department of Paediatrics, General Hospital of Bolzano, Italy.
Abstract:
The case of a 17-year-old male with isolated hypersecretion of dehydroepiandrosterone sulphate (DHEAS) is described. Cushing syndrome, congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency, an androgen producing adrenal tumour, and elevated plasma DHEAS due to an increased renal threshold were excluded. Selective renal vein catheterization confirmed bilateral, isolated adrenal DHEAS hypersecretion. The dexamethasone suppression suggests a functional nature of this alteration. This condition has to be considered in the differential diagnosis of excessive adrenal androgen production in males, or of hirsutism in females.
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