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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Micro-RNA Expression and Function in Lymphomas.

Sukhinder K Sandhu1, Carlo M Croce, Ramiro Garzon

  • 1Department of Molecular Virology, Immunology and Medical Genetics, Molecular and Cellular Developmental Biology Program, The Ohio State University Medical Center, Columbus, OH 43210, USA.

Advances in Hematology
|April 5, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate genes and are crucial for cell function. Studying miRNA expression in lymphomas offers insights into disease and potential new therapies for diagnosis and treatment.

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Last Updated: Jun 3, 2026

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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene regulation.
  • Dysregulation of miRNA expression is implicated in the development of various diseases, including cancers.
  • Lymphomas are a heterogeneous group of cancers originating from lymphocytes, with complex underlying molecular mechanisms.

Purpose of the Study:

  • To elucidate the expression patterns of miRNAs in different types of lymphomas.
  • To investigate the functional roles of specific miRNAs in lymphomagenesis.
  • To explore the potential of miRNAs as diagnostic biomarkers and therapeutic targets for lymphomas.

Main Methods:

  • Analysis of miRNA expression profiles in lymphoma patient samples and animal models.
  • Functional studies using cell lines and genetically modified animal models to assess the impact of miRNA modulation.
  • Bioinformatic analysis to identify miRNA-target interactions and regulatory networks.

Main Results:

  • Significant alterations in miRNA expression were observed in various lymphoma subtypes compared to normal B cells.
  • Specific miRNAs were identified as key regulators of lymphoma cell proliferation, survival, and drug resistance.
  • miRNA expression signatures showed potential for differentiating lymphoma subtypes and predicting patient outcomes.

Conclusions:

  • MicroRNAs are integral to the pathogenesis of lymphomas and represent promising biomarkers.
  • Targeting specific miRNAs offers a novel therapeutic strategy for lymphoma treatment.
  • Further research into miRNA-based therapies could revolutionize lymphoma diagnosis and management.