Related Experiment Video
Updated: Jun 3, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
Published on: March 28, 2013
Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function
1Biozentrum, Division of Pharmacology/Neurobiology, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. christoph.handschin@unibas.ch
Abstract:
Proteins belonging to the peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) family are key regulators of cellular energy homeostasis in a number of oxidative tissues, including skeletal muscle. While the regulation and function of PGC-1α seems central to muscle fibre plasticity in endurance exercise, the role of PGC-1β in this tissue is less clear. Wright et al. (Diabetologia, DOI: 10.1007/s00125-011-2068-x ) provide evidence for a protective effect of moderately elevated PGC-1β in electroporated rat skeletal muscle against high-fat-diet-induced insulin resistance, at least in part by promoting the oxidation of long chain acyl-CoA entities and the elimination of reactive oxygen species. These data provide important insights into the biological role of PGC-1β in skeletal muscle and imply novel therapeutic avenues for improving peripheral insulin sensitivity.
More Related Videos
12:32High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
Published on: January 23, 2018
08:01Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
Related Concept Videos
Cell Specific Gene Expression
cAMP-dependent Protein Kinase Pathways
Master Transcription Regulators
GPCRs Regulate Adenylyl Cylase Activity
Two...
Regulation of Metabolism
PI3K/mTOR/AKT Signaling Pathway