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Cyclic α,β-peptoid octamers with differing side chain patterns: synthesis and conformational investigation

Emiliana De Santis1, Thomas Hjelmgaard, Sophie Faure

  • 1Medway School of Pharmacy, Universities of Kent and Greenwich at Medway, Central Avenue, Chatham Maritime, Kent, UK.

Amino Acids
|April 5, 2011
PubMed
Summary

Researchers synthesized and studied three alpha,beta-peptoid octamers. Compound C exhibited enhanced conformational stability, linked to its specific N-2-(benzyloxy)ethyl side chain, as revealed by X-ray crystallography and circular dichroism.

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