Memantine in moderate to severe Alzheimer's disease: an observational post-marketing study
Michael Rainer1, A Wuschitz, C Jagsch
1Memory Clinic and Psychiatric Department, Donauspital Sozialmedizinisches Zentrum Ost, Langobardenstrasse 122, 1220, Wien, Austria. Michael.Rainer@wienkav.at
Abstract:
Memantine is an N-methyl-D: -aspartate (NMDA) receptor antagonist, approved for the treatment of moderate to severe Alzheimer's disease (AD). We conducted a 4-month observational, post-marketing, Austrian study of memantine in 377 outpatients with moderate to severe AD. In this 'real-life' setting, memantine was well-tolerated, and produced benefits in cognition (Mini-Mental State Examination), activities of daily living (Activities of Daily Living score), and global function (Clinical Global Impression scale). Treatment effects were apparent in both pre-treated and treatment-naïve patient subgroups.
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