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Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
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Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

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Analysis of average telomere length in cultured human cells

Dan Liu1

  • 1Department of Biochemistry and Molecular Biology, Cell-based Assay Screening Service Core, Baylor College of Medicine, Houston, TX, USA. danl@bcm.edu

Methods in Molecular Biology (Clifton, N.J.)
|April 5, 2011
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...