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Bipolar II disorder in six sisters.

J R DePaulo¹, S G Simpson, J O Gayle

¹Johns Hopkins University School of Medicine, Baltimore, MD.

Journal of Affective Disorders

|August 1, 1990

Summary

Type II bipolar disorder (BPII) may be distinct from Type I bipolar disorder (BPI), evidenced by differing illness courses and family patterns. Further research, including molecular genetics, is needed to confirm BPII

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Area of Science:

Psychiatry
Genetics
Clinical Psychology

Background:

Distinguishing between Type I bipolar disorder (BPI) and Type II bipolar disorder (BPII) is clinically significant.
Previous research indicates differences in illness course, treatment response, comorbidity, and familial aggregation between BPI and BPII.

Purpose of the Study:

To present a family study supporting the hypothesis that BPII is a distinct diagnostic entity.
To highlight the potential genetic basis for BPII, suggesting it 'breeds true' within families.

Main Methods:

Clinical case report of a family with multiple affected members.
Review of existing literature on BPI and BPII differentiating factors.
Proposal for future molecular genetic studies.

Main Results:

A family with six affected sisters and other relatives exhibiting BPII.
This familial aggregation provides further evidence for the distinctiveness of BPII.
The diagnostic stability of BPII remains a challenge for clear differentiation.

Conclusions:

The findings support the notion that BPII may be a distinct disorder, particularly within certain families.
Further research, especially utilizing molecular genetic approaches, is crucial to definitively establish BPII's distinctness from BPI and unipolar disorders.

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