Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Survival outcomes of adjuvant therapy in resected stage III melanoma: Results from a real-life cohort study (TAMARIS).

European journal of cancer (Oxford, England : 1990)·2026
Same author

PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy.

Journal of translational medicine·2026
Same author

Comparison of an AI-based prognostic assay with gene expression profiling in early-stage melanoma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

[Open data: main objective achieved for the French Society of Pathology's data challenges].

Annales de pathologie·2026
Same author

Multimodal noninvasive cutaneous imaging of Spitz and Reed naevi in children: a preliminary case series study.

Clinical and experimental dermatology·2025
Same author

The Effect of Myrtacine and Celastrol-Enriched Extract on Cutibacterium acnes Extracellular Vesicles.

International journal of dermatology·2025

Related Experiment Video

Updated: Jun 3, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

Is antigen specificity the key to efficient adoptive T-cell therapy?

Nathalie Labarriere1, Amir Khammari, Francois Lang

  • 1Unite Mixte de Recherche Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Canerologie Nantes-Angers, Nantes, France.

Immunotherapy
|April 6, 2011
PubMed
Summary

Adoptive cell therapy for melanoma shows promise, particularly in earlier stages and with lymphodepleting regimens. New methods focus on antigen-specific T cells, including HLA-peptide multimer selection, for improved melanoma treatment.

More Related Videos

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Related Experiment Videos

Last Updated: Jun 3, 2026

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
09:28

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Adoptive T cell therapy is a promising strategy for melanoma treatment.
  • Early trials with polyclonal tumor-infiltrating lymphocytes yielded limited results.
  • Encouraging outcomes observed in adjuvant settings and with lymphodepleting regimens.

Purpose of the Study:

  • To explore strategies for enhancing adoptive T cell therapy in melanoma.
  • To investigate methods for achieving antigen specificity in T cell therapies.
  • To propose an alternative approach for selecting antigen-specific T cells.

Main Methods:

  • Utilizing antigen-specific cytotoxic T-lymphocyte clones.
  • Employing allogeneic transfer of high-avidity T-cell receptors.
  • Developing a novel strategy using magnetic beads coated with HLA-peptide multimers for T cell selection.

Main Results:

  • Antigen specificity has been achieved through T-cell receptor infusion, leading to clinical responses.
  • The proposed method offers an alternative for selecting antigen-specific T cells.
  • Future research may combine adoptive immunotherapy with targeted signaling pathway therapies.

Conclusions:

  • Adoptive T cell therapy holds significant potential for melanoma treatment.
  • Enhancing antigen specificity is crucial for improving therapeutic efficacy.
  • Combining adoptive immunotherapy with other strategies may lead to better outcomes in melanoma.