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Enterotoxemia in rabbits.

N M Patton, H T Holmes, R J Riggs

    Laboratory Animal Science
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Clostridium perfringens Type E iota toxin was found in rabbits with enteritis. This toxin caused lethal cecal lesions, but antiserum neutralized its effects in toxicity tests.

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    Area of Science:

    • Veterinary Pathology
    • Microbiology
    • Toxicology

    Background:

    • Enteritis complex is a significant cause of mortality in rabbits.
    • Clostridium perfringens is a known bacterial pathogen in various animal species.
    • The role of specific toxin types in rabbit enteritis requires further elucidation.

    Purpose of the Study:

    • To investigate the presence and role of Clostridium perfringens Type E iota toxin in rabbit enteritis.
    • To characterize the pathological findings associated with this condition.
    • To evaluate the efficacy of Clostridium perfringens Type E antiserum.

    Main Methods:

    • Detection of Clostridium perfringens Type E iota toxin in cecal contents of deceased rabbits.
    • Histopathological examination of cecal tissues to identify characteristic lesions.

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  • Rabbit toxicity assays using cecal contents, with and without Clostridium perfringens Type E antiserum.

    • Main Results:

    • Clostridium perfringens Type E iota toxin was identified in 50% (23/46) of rabbits with enteritis.
    • Hemorrhage and edema in the cecum were the most prominent pathological findings.
    • Cecal contents containing the toxin were lethal to young rabbits, but this lethality was prevented by incubation with specific antiserum.

    Conclusions:

    • Clostridium perfringens Type E iota toxin is implicated in the pathogenesis of enteritis complex in rabbits.
    • The toxin likely contributes to the observed cecal hemorrhage and edema.
    • Clostridium perfringens Type E antiserum demonstrates protective effects against the toxin's lethal activity.