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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Updated: Jun 3, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma in adults (acute).

Gustavo Rodrigo¹

¹Departmento de Emergencia, Hospital Central de las Fuerzas Armadas, Uraguay.

BMJ Clinical Evidence

|April 6, 2011

Summary

This summary is machine-generated.

This review examines treatments for acute asthma, including medications like beta2 agonists and corticosteroids, and interventions such as oxygen and magnesium sulfate. Evidence on effectiveness and safety for various asthma management strategies is presented.

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Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

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Last Updated: Jun 3, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Pulmonology
Clinical Medicine
Pharmacology

Background:

Asthma affects 10% of adults, with 5% experiencing severe, treatment-resistant disease.
Severe asthma increases mortality risk; mild to moderate cases also face exacerbations.
Current asthma management often follows stepwise protocols, but this review focuses on evidence for specific interventions.

Purpose of the Study:

To systematically review the effects of various treatments for acute asthma.
To evaluate the effectiveness and safety of different asthma interventions.

Main Methods:

Systematic review of 100 studies (reviews, RCTs, observational studies) up to April 2010.
Searched Medline, Embase, The Cochrane Library, and other databases.
Included harms alerts from FDA and MHRA.

Main Results:

Evaluated interventions using GRADE methodology for evidence quality.
Included beta2 agonists, corticosteroids, education, heliox, magnesium sulfate, mechanical ventilation, and oxygen supplementation.
Assessed various delivery methods for medications (e.g., nebulized, inhaled, IV).

Conclusions:

Presents evidence on the effectiveness and safety of numerous acute asthma interventions.
Covers a wide range of pharmacological and non-pharmacological treatments.
Provides a comprehensive overview for managing acute asthma episodes.