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Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
Published on: March 6, 2018
Adiposity and pulmonary function: relationship with body fat distribution and systemic inflammation.
Andréa Lessard1, Nathalie Alméras, Hélène Turcotte
1Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, 2725 chemin Sainte-Foy, Québec, QC, Canada.
Summary
Obesity impacts lung function primarily through mechanical factors, not inflammation. Body fat distribution, not just BMI, is key to understanding these pulmonary changes.
Area of Science:
- Pulmonary Medicine
- Obesity Research
- Inflammation Studies
Background:
- Obesity is linked to altered pulmonary function and increased systemic inflammation.
- Understanding the interplay between adiposity, fat distribution, inflammatory markers, and lung function is crucial.
Purpose of the Study:
- To explore the relationships among adiposity, body fat distribution indices, serum inflammatory markers, and pulmonary function.
- To investigate whether inflammatory markers mediate the association between obesity and lung function.
Main Methods:
- Cross-sectional analysis of 282 non-smoking, sedentary men without respiratory diseases.
- Measurements included Body Mass Index (BMI), waist circumference (WC), visceral and subcutaneous adipose tissue (AT), and pulmonary function tests (RV, VC, ERV).
- Serum levels of leptin, adiponectin, TNF-α, and hs-CRP were analyzed.
Main Results:
- In subjects with metabolic syndrome, expiratory reserve volume (ERV) and residual volume (RV) were significantly associated with BMI, WC, visceral, and subcutaneous AT.
- Vital capacity (VC) correlated with visceral and subcutaneous AT.
- Leptin levels strongly correlated with BMI, WC, and both visceral and subcutaneous AT. Adiponectin showed associations with WC and AT in non-metabolic syndrome subjects.
- After adjusting for anthropometric measures, no significant correlations were found between pulmonary function (ERV, RV, VC) and serum inflammatory markers (leptin, adiponectin, TNF-α, hs-CRP).
Conclusions:
- The impact of obesity on lung function in healthy individuals appears to be predominantly mediated by mechanical factors.
- Both overall adiposity (BMI) and the specific pattern of fat distribution are important considerations when examining the relationship between obesity and pulmonary function.
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