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Updated: Jun 3, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Expression of cyclophilin A and CD147 during skin aging
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To investigate the role of cyclophilin A (CypA) and CD147 in the process of skin aging.
Methods:
Twenty cases of tissue samples from junior group(<15 years old), middle age group(30-40 years old)or old age group (>65 years old) were collected from photophobic and exposal parts of skin, respectively. Immunohistochemistry (IHC) and in situ hybridization (ISH) were carried out to semi-quantitatively detect the expression level of CyPA and CD147.
Results:
IHC demonstrated that both CyPA and CD147 were expressed in both photophobic and exposal parts of normal human skin in all 3 groups. The expression levels of both CyPA and CD147 were increased with increase in age. There were significant differences in both CyPA and CD147 expression among 3 groups (P<0.05). CyPA and CD147 were also positively correlated in all 3 groups. Similar results were achieved by ISH.
Conclusion:
The interaction between CD147 and CyPA might play an important role in the process of skin aging.
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