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Related Experiment Video

Updated: Jun 3, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Rings in the neonate.

C B Hackett¹, M A McAleer, B F O'Donnell

¹Department of Dermatology, The Children's University Hospital, Temple St, Dublin 1.

Irish Medical Journal

|April 7, 2011

Summary

This summary is machine-generated.

Neonatal lupus erythematosus (NLE) is a rare condition caused by maternal autoantibodies. This case highlights characteristic skin lesions and the importance of screening for other organ involvement in infants with NLE.

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Area of Science:

Neonatal immunology
Autoimmune diseases in neonates
Maternal-fetal medicine

Background:

Neonatal lupus erythematosus (NLE) is an uncommon autoimmune condition in newborns.
It results from transplacental transfer of maternal autoantibodies, primarily anti-Ro/SSA and anti-La/SSB.
Common NLE manifestations include skin lesions and congenital heart block.

Observation:

This report details a case of cutaneous NLE.
The patient presented with the characteristic annular eruption associated with NLE.
The case underscores the visual diagnostic features of NLE skin manifestations.

Findings:

Maternal autoantibodies crossing the placenta are the primary cause of NLE.
Cutaneous lupus lesions, like the annular eruption, are a key clinical sign.
Congenital complete heart block is another significant, though less frequent, manifestation.

Implications:

Early recognition of NLE is crucial for timely intervention.
Thorough investigation for associated organ involvement (cardiac, hepatic, hematologic) is essential.
Maternal counseling is vital to inform about recurrence risks in future pregnancies and management strategies.