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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
06:23

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

Coagulation abnormalities in patients with chronic liver disease in Pakistan

Sohail Ahmed Siddiqui1, Mubashir Ahmed, Muhammad Hanif Ghani

  • 1Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh.

JPMA. the Journal of the Pakistan Medical Association
|April 7, 2011
PubMed

Insights

Coagulation abnormalities are common in chronic liver disease (CLD). Decreased platelet counts and fibrinogen levels, not PT or aPTT, correlate with gastrointestinal bleeding risk in CLD patients.

Area of Science:

  • Hepatology
  • Hematology
  • Gastroenterology

Background:

  • Chronic liver disease (CLD) frequently presents with complex coagulation abnormalities.
  • Understanding these hemostatic derangements is crucial for managing complications like gastrointestinal (GI) bleeding.

Purpose of the Study:

  • To investigate the spectrum of coagulation abnormalities in CLD patients.
  • To determine the association between specific clotting test results and the risk of GI bleeding.

Main Methods:

  • Adult CLD patients admitted to a tertiary care hospital were enrolled.
  • Coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels were assessed.
  • Relative risk (RR) was calculated to evaluate the association between abnormal tests and GI bleeding.

Main Results:

  • Profound abnormalities were observed: prolonged PT (88%), elevated aPTT (71%), decreased platelets (37%), and low fibrinogen (15%).
  • Decreased platelet counts (RR = 1.96) and fibrinogen levels (RR = 1.47) showed a positive association with GI bleeding.
  • Prothrombin time (RR = 1.02) and aPTT (RR = 0.83) did not show a significant relationship with GI bleeding risk.

Conclusions:

  • Coagulation derangements are prevalent in CLD patients.
  • Reduced platelet counts and fibrinogen levels are linked to an increased risk of GI bleeding.
  • While PT and aPTT are not significant predictors of GI bleeding in CLD, they remain valuable prognostic markers.
Abstract

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