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Updated: Jun 3, 2026
10:53
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
[Stability of probucol-polyvinylpyrrolidone solid dispersion systems].
Yoshitada Kubo1, Naomi Yagi, Hitoshi Sekikawa
1Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan. y-kubo@hoku-iryo-u.ac.jp
Summary
Probucol-polyvinylpyrrolidone K30 solid dispersions show good light stability but can partially crystallize under high humidity. Proper packaging ensures stability for up to five months under room conditions.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Solid dispersion technology enhances drug solubility and bioavailability.
- Probucol is a lipid-lowering agent with poor aqueous solubility.
Purpose of the Study:
- To evaluate the photostability and humidity-induced degradation of probucol-polyvinylpyrrolidone K30 solid dispersions.
- To assess the impact of storage conditions on the physical state and dissolution of probucol.
Main Methods:
- Preparation of probucol-polyvinylpyrrolidone K30 solid dispersions (1:9 w/w).
- Exposure to light (10000 lx) and storage at elevated temperature (30°C) with high relative humidity (75%, 92%).
- Analysis using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and High-Performance Liquid Chromatography (HPLC).
Main Results:
- Solid dispersions retained 84% probucol after 7 days of light exposure, indicating good photostability.
- Significant weight gain (22-43%) and decreased probucol concentration upon dissolution were observed under high humidity.
- Partial crystallization of probucol during storage under humid conditions was suggested by HPLC analysis of filtered residues.
Conclusions:
- Probucol-polyvinylpyrrolidone K30 solid dispersions exhibit good photostability.
- High humidity can induce partial crystallization of probucol, affecting its dissolution characteristics.
- Heat-sealed packaging and storage under room conditions or in light-resistant containers ensure stability for up to 5 months.
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