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Re-Arterialized Rat Partial Liver Transplantation with an in vivo Vessel-Oriented 70% Hepatectomy
Published on: April 8, 2018
Where are we today in split liver transplantation?
Johnny C Hong1, Hasan Yersiz, Ronald W Busuttil
1The Dumont-UCLA Transplant and Liver Cancer Centers, Pfleger Liver Institute, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, California 90095-7054, USA. johnnyhong@mednet.ucla.edu
Current Opinion in Organ Transplantation
|April 7, 2011
Summary
Split liver transplantation (SLT) using partial deceased donor grafts offers a durable, life-saving option. Careful graft-to-recipient matching in specialized centers is key for long-term patient and graft survival.
Area of Science:
- Hepatology
- Transplantation Surgery
- Organ Donation
Background:
- Surgical innovations with partial liver grafts improve organ availability.
- Outcomes data for split liver transplantation (SLT) are currently conflicting.
- This review focuses on long-term outcomes and survival predictors in SLT.
Purpose of the Study:
- To review the current status of split liver transplantation (SLT).
- To analyze long-term patient and graft survival outcomes after SLT.
- To identify predictors influencing survival in SLT recipients.
Main Methods:
- Review of current literature on split liver transplantation.
- Analysis of existing data on patient and graft survival.
- Identification of factors affecting outcomes in SLT.
Main Results:
- Conventional SLT is a durable, life-saving procedure.
- Full left-right SLT for two adults shows promise but lacks wide applicability.
- Predictors of reduced survival include high MELD scores, retransplants, prolonged cold ischemia, and low-volume centers.
Conclusions:
- Conventional SLT in specialized centers yields long-term survival comparable to whole-organ transplantation.
- Full left-right SLT for two adults is still experimental.
- Liver splitting expands the donor pool and is crucial for patients needing transplants; optimal pairing is vital.
