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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Circadian Rhythms and Gene Regulation

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Related Experiment Video

Updated: Jun 3, 2026

Real-Time Void Spot Assay

Real-Time Void Spot Assay

Published on: February 10, 2023

Circadian rhythms in voiding function and dysfunction.

Sehyung Cho¹, Dong-Hee Han, Dong-Hee Kim

¹Department of Physiology, Neurodegeneration Control Research Center, Kyung Hee University School of Medicine, Seoul, Korea.

International Neurourology Journal

|April 7, 2011

Summary

Circadian rhythms influence daily fluid intake and urine production. Further research is needed to understand the underlying molecular mechanisms controlling these bodily functions.

Keywords:

Circadian Clockwork Diurnal Sleep Voiding

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Area of Science:

Physiology
Chronobiology
Urology

Background:

Circadian rhythms in fluid balance are established in humans and rodents.
The precise mechanisms regulating these rhythms, particularly voiding function, remain largely unknown.

Purpose of the Study:

To explore the potential role of molecular clockwork in controlling circadian rhythms of voiding function.
To highlight the need for further investigation into the circadian control of urinary function and dysfunction.

Main Methods:

This study is a review and conceptual analysis.
It synthesizes current knowledge on circadian rhythms and molecular clock mechanisms.

Main Results:

Elucidation of molecular clockwork provides a framework for understanding circadian control of physiological processes.
New opportunities exist to investigate the link between molecular clocks and voiding function.

Conclusions:

Understanding the molecular basis of circadian rhythms in fluid balance and voiding is crucial.
Further research into circadian control of urinary function is warranted and requires attention from the scientific community.