Related Experiment Video
Updated: Jun 3, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Rapid UV light-triggered macromolecular click conjugations via the use of o-quinodimethanes
Till Gruendling1, Kim K Oehlenschlaeger, Elena Frick
1Preparative Macromolecular Chemistry, Karlsruhe Institute of Technology, Engesserstr. 18, 76128 Karlsruhe, Germany.
Abstract:
Shining a light on click chemistry: The use of UV-radiation as trigger signal provides a facile means to obtain spatial and temporal control over polymer conjugation reactions in addition to providing a further means of achieving orthogonality in click transformations. In the current contribution, UV-radiation was employed to induce a highly efficient Diels-Alder conjugation of polymeric building blocks via the photo-induced in situ formation of highly reactive cis-dienes from a 2-methylbenzophenone precursor.
Related Concept Videos
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Radical Chain-Growth Polymerization: Overview

