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Updated: Jun 3, 2026

Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis
Published on: September 29, 2023
Glycan microarrays for decoding the glycome
Cory D Rillahan1, James C Paulson
1Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA. rillahan@scripps.edu
Abstract:
In the last decade, glycan microarrays have revolutionized the analysis of the specificity of glycan-binding proteins (GBPs), providing information that simultaneously illuminates the biology mediated by them and decodes the informational content of the glycome. Numerous methods have emerged for arraying glycans in a "chip" format, and glycan libraries have been assembled that address the diversity of the human glycome. Such arrays have been successfully used for analysis of GBPs, which mediate mammalian biology, host-pathogen interactions, and immune recognition of glycans relevant to vaccine production and cancer antigens. This review covers the development of glycan microarrays and applications that have provided insights into the roles of mammalian and microbial GBPs.
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