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[Lipoprotein (a)--a further risk factor in arteriosclerosis?]
1Medizinische Klinik, Klinikum Grosshadern der Universität München.
Fortschritte Der Medizin
|October 10, 1990
Summary
Lipoprotein (a) is a genetically determined risk factor for premature arteriosclerosis. Its levels are difficult to modify with standard treatments, suggesting a unique role in cardiovascular disease.
Area of Science:
- Biochemistry
- Epidemiology
- Cardiovascular Medicine
Context:
- Lipoprotein (a) [Lp(a)] has been recognized since 1963 but recently gained attention as a significant risk factor.
- Epidemiological studies highlight Lp(a) as a contributor to premature arteriosclerosis.
- Lp(a) concentration is genetically determined, leading to high inter-individual variability.
Purpose:
- To review the current understanding of lipoprotein (a) as a risk factor for arteriosclerosis.
- To discuss the characteristics of Lp(a) and its limited response to conventional interventions.
- To explore the potential link between Lp(a), arteriosclerosis, and thrombosis.
Summary:
- Lipoprotein (a) is structurally similar to low-density lipoprotein (LDL) but with distinct properties.
- Serum concentrations of Lp(a) are genetically controlled and show considerable variation among individuals.
- Standard dietary and pharmacological interventions have minimal impact on reducing Lp(a) levels.
Impact:
- Highlights Lp(a) as a distinct and genetically influenced risk factor for cardiovascular disease.
- Underscores the limitations of current therapeutic strategies in managing Lp(a) levels.
- Suggests a potential etiological connection between Lp(a), arteriosclerosis, and thrombotic events due to its homology with plasminogen.