Posterior reversible encephalopathy syndrome in a child with cyclical vomiting and hypertension: a case report

Zakareya Gamie1, Akheel Rizwan, Frances G Balen

  • 1Department of Paediatrics, Pontefract General Infirmary, Pontefract, UK. ugm1zg@doctors.org.uk.

Insights

Posterior reversible encephalopathy syndrome (PRES) is rare in children. This case highlights its association with cyclical vomiting and hypertension, emphasizing early radiological diagnosis for effective treatment.

Area of Science:

  • Neurology
  • Pediatrics
  • Radiology

Background:

  • Posterior reversible encephalopathy syndrome (PRES) presents with headache, nausea, vomiting, seizures, and visual disturbances.
  • Characteristic radiological findings aid in PRES diagnosis within a suitable clinical context.
  • Prompt diagnosis facilitates the institution of appropriate clinical therapy.

Purpose of the Study:

  • To present a case of posterior reversible encephalopathy syndrome (PRES) in a pediatric patient.
  • To explore the association between PRES, cyclical vomiting, and hypertension in a child.
  • To discuss the diagnostic challenges and clinical recovery patterns in pediatric PRES.

Main Methods:

  • A case presentation of a 10-year-old Caucasian girl diagnosed with PRES.
  • Initial diagnosis of cyclical vomiting and hypertension preceded the PRES diagnosis.
  • Magnetic resonance imaging (MRI) was utilized to identify radiological features.

Main Results:

  • The patient was diagnosed with posterior reversible encephalopathy syndrome (PRES).
  • An association was noted between PRES, cyclical vomiting, and hypertension.
  • Radiological abnormalities on MRI showed resolution over time, but clinical recovery was not parallel.

Conclusions:

  • Posterior reversible encephalopathy syndrome (PRES) is an uncommon pediatric disorder.
  • Early recognition of radiological features is crucial for diagnosing PRES, as clinical symptoms can be nonspecific.
  • This case is the first to report an association between PRES, cyclical vomiting, and hypertension, with a noted discrepancy between radiological resolution and clinical recovery.
Abstract

Related Concept Videos

Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...