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Updated: Jun 3, 2026

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
Published on: October 20, 2023
Rehabilitating a brain with Alzheimer's: a proposal
Gonzalo Emiliano Aranda-Abreu1, María Elena Hernández-Aguilar, Jorge Manzo Denes
1Programa de Neurobiología, Universidad Veracruzana, Xalapa, Mexico. garanda@uv.mx
This study proposes a novel Alzheimer's disease (AD) therapy. Repairing neuronal membranes before conventional drugs may enhance treatment effectiveness for AD patients.
Area of Science:
- Neurodegenerative Disorders
- Geriatric Medicine
- Pharmacology
Background:
- Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, primarily affecting individuals over 65.
- Advanced age is the principal risk factor for AD development.
- The precise origin and triggering mechanisms of AD remain unknown despite extensive research.
Observation:
- Current FDA-approved AD drugs (tacrine, donepezil, rivastigmine, galantamine, memantine) can only temporarily slow disease progression.
- These drugs may have limited efficacy due to their inability to effectively target degenerating neurons.
Findings:
- A proposed alternative therapy involves initial repair of neuronal membranes.
- This is followed by conventional drug treatments for Alzheimer's disease.
Implications:
- Rehabilitating degenerating neurons could significantly improve the effectiveness of existing AD medications.
- This novel therapeutic approach holds potential for better treatment outcomes in Alzheimer's patients.
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