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Direct genetic analysis of ten cancer cells: tuning sensor structure and molecular probe design for efficient mRNA

Elizaveta Vasilyeva1, Brian Lam, Zhichao Fang

  • 1Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Angewandte Chemie (International Ed. in English)
|April 8, 2011
PubMed
Abstract

No abstract available in PubMed .

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...