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Published on: November 9, 2019
Total synthesis of hoiamide C
Lei Wang1, Zhengshuang Xu, Tao Ye
1Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, China.
Organic Letters
|April 9, 2011
Summary
Researchers synthesized Hoiamide C in 16 steps, achieving a 1.8% yield. This synthesis unambiguously confirmed the complex natural product
Area of Science:
- Organic Chemistry
- Natural Product Synthesis
Background:
- Hoiamide C is a complex natural product.
- Its structural elucidation and synthesis are of significant interest.
Purpose of the Study:
- To achieve the total synthesis of Hoiamide C.
- To unambiguously confirm the proposed structure of Hoiamide C through synthesis.
Main Methods:
- Multi-step organic synthesis.
- Utilized homoallylic alcohol 18 as a starting material.
Main Results:
- Successful synthesis of Hoiamide C in 16 steps.
- Achieved an overall yield of 1.8% for the synthetic route.
- The synthesized compound's data unequivocally confirmed the structure.
Conclusions:
- The total synthesis of Hoiamide C was accomplished.
- The synthetic route provides unambiguous structural confirmation.
- This work contributes to the field of natural product synthesis.
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