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Related Concept Videos

Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.

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Related Experiment Video

Updated: Jun 3, 2026

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
08:05

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy

Published on: May 27, 2021

Endocytosis and signaling.

Harald W Platta1, Harald Stenmark

  • 1Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0310 Oslo, Norway. Harald.Platta@rr-research.no

Current Opinion in Cell Biology
|April 9, 2011
PubMed
Summary

Cellular signaling relies on endocytosis to internalize receptors, influencing cellular responses. Endocytosis also forms signaling complexes within endosomes, creating specialized signaling platforms.

Area of Science:

  • Cell Biology
  • Molecular Signaling
  • Endocytosis

Background:

  • Cellular signaling processes are regulated by endocytosis, the internalization of plasma membrane receptors.
  • Receptor clearance via endocytosis impacts cellular responsiveness to external stimuli.
  • Endocytosis facilitates the assembly of signal transduction complexes within endosomes.

Purpose of the Study:

  • To explore the role of endocytosis in forming endosome-specific signal transduction complexes.
  • To understand how receptor and signaling molecule trafficking within endosomes controls complex activity.
  • To investigate the biogenesis and dynamics of endocytic compartments as signaling platforms.

Main Methods:

  • Investigated receptor internalization and trafficking dynamics.

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Imaging FITC-dextran as a Reporter for Regulated Exocytosis
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Imaging FITC-dextran as a Reporter for Regulated Exocytosis

Published on: June 20, 2018

Related Experiment Videos

Last Updated: Jun 3, 2026

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy
08:05

Visualizing Membrane Ruffle Formation using Scanning Electron Microscopy

Published on: May 27, 2021

Imaging FITC-dextran as a Reporter for Regulated Exocytosis
04:50

Imaging FITC-dextran as a Reporter for Regulated Exocytosis

Published on: June 20, 2018

  • Analyzed the formation and composition of endosomal signaling complexes.
  • Studied the biogenesis and maturation of early, recycling, and late endosomes.

    • Main Results:

    • Endocytosis governs receptor clearance, defining cellular signaling quality.
    • Endosomes serve as platforms for signal transduction complex assembly and turnover.
    • Dynamic interconversion and subdomain generation characterize endocytic organelles.

    Conclusions:

    • Endocytosis is crucial for both receptor regulation and the formation of endosomal signaling platforms.
    • The trafficking of molecules within endosomes dictates the activity of signaling complexes.
    • Endosomal compartments are dynamic and multifunctional, acting as specialized signaling hubs.