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Related Concept Videos

Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding01:22

Protein Folding

Overview
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...

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Updated: Jun 3, 2026

Interview: Protein Folding and Studies of Neurodegenerative Diseases
19:50

Interview: Protein Folding and Studies of Neurodegenerative Diseases

Published on: July 16, 2008

Novel proteins: from fold to function.

Betsy A Smith1, Michael H Hecht

  • 1Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

Current Opinion in Chemical Biology
|April 9, 2011
PubMed
Summary
This summary is machine-generated.

De novo protein design has advanced rapidly, enabling the creation of novel, functional proteins. These designed proteins exhibit diverse functions, from metal binding to enzymatic catalysis, with applications in medicine and engineering.

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Last Updated: Jun 3, 2026

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Area of Science:

  • Biochemistry and Molecular Biology
  • Protein Engineering
  • Synthetic Biology

Background:

  • The field of de novo protein design has matured significantly over the past two decades.
  • Recent advancements allow for the creation and selection of novel, functionally active proteins from scratch.
  • This review focuses on the latest developments in designing proteins with specific functions.

Purpose of the Study:

  • To review recently reported de novo functional proteins.
  • To highlight the diverse approaches used in de novo protein design.
  • To showcase the range of functions and applications of designed proteins.

Main Methods:

  • Rational design strategies.
  • Computational optimization techniques.
  • Selection from combinatorial libraries.

Main Results:

  • Successful design and selection of novel functional proteins.
  • Demonstrated functions include metal binding and enzymatic catalysis.
  • Designed proteins show potential for applications in engineering and medicine.
  • Some designed proteins can perform life-sustaining functions in vivo.

Conclusions:

  • De novo protein design is a powerful tool for creating proteins with tailored functions.
  • The field offers promising avenues for advancements in biotechnology, medicine, and fundamental biology.
  • Continued innovation in design methodologies will expand the capabilities of engineered proteins.