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NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development

Masaki Kashiwada1, Nhat-Long L Pham, Lecia L Pewe

  • 1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Blood
|April 9, 2011
PubMed
Summary

The transcription factor NFIL3 is crucial for developing a specific type of dendritic cell (DC), the CD8α(+) conventional DC (cDC). Without NFIL3, mice lack these essential CD8α(+) cDCs, impacting immune responses.

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