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Functional disability profiles in amnestic mild cognitive impairment.
Yen-Chi Yeh1, Ker-Neng Lin, Wei-Ta Chen
1Division of Neurology, Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei, Taiwan, ROC.
Dementia and Geriatric Cognitive Disorders
|April 9, 2011
Summary
Instrumental activities of daily living (IADL) are impaired in both single-domain and multiple-domain amnestic mild cognitive impairment (aMCI). Assessing IADL function aids in managing daily living activities for individuals with aMCI.
Area of Science:
- Neuroscience
- Gerontology
- Cognitive Science
Background:
- Instrumental activities of daily living (IADL) impairment is a known characteristic of mild cognitive impairment (MCI).
- Functional disability severity in amnestic MCI (aMCI) can predict the progression to Alzheimer's disease (AD).
- This study focuses on characterizing the functional profiles of aMCI within a Chinese population.
Purpose of the Study:
- To investigate and compare the functional profiles of single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI).
- To assess IADL performance in a Chinese population with different cognitive statuses.
- To identify the relationship between cognitive function and IADL performance in aMCI.
Main Methods:
- Compared Disability Assessment for Dementia scores among normal controls (n=64), sd-aMCI (n=56), md-aMCI (n=94), and mild AD patients (n=102).
- Assessed IADL performance across various subscales including meal preparation, telephoning, finance, medications, housework, and leisure.
- Utilized Mini-Mental State Examination and Modified Trail-Making Test Part B for neuropsychological assessment.
Main Results:
- Both sd-aMCI and md-aMCI groups exhibited significantly more impaired IADL items compared to normal controls.
- IADL scores for aMCI groups were intermediate, falling between those of controls and mild AD patients.
- sd-aMCI showed deficits in 7 IADL items, while md-aMCI demonstrated deficits across all 14 IADL items, indicating broader functional impairment.
Conclusions:
- IADL impairment is present in both sd-aMCI and md-aMCI.
- Functional ability assessment is crucial for evaluating aMCI patients.
- Incorporating IADL assessments can help clinicians provide targeted recommendations for maintaining daily functioning in aMCI.
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