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Effect of telmisartan in experimentally induced diabetetes mellitus in rats
1Department of Clinical Pharmacology, Mansoura University, Egypt.
Background:
Increased oxidative stress is involved in the pathogenesis of diabetic nephropathy and neuropathy. Angiotensin II is a know factor in the pathogenesis of diabetic complications. The protective effects of ACEIs is known in diabetic nephropathy. Thus, Angiotensin receptor antagonists may have the same role. In this study, possible antidiabetic effect of Telmisartan and its tissues antioxidant effect in (STZ) induced diabetic rats, were studied
Methods:
The present study was done on 40 rats. They were divided into 2 main groups. Group I: 10 rats as control group, received distilled water. Group II: 30 rats subdivided into 3 equal subgroups as follow: Subgroup IIA: control diabetic group, received 55 mg/kg STZ intraperitoneally. Sub group IIB: diabetic rats, received 10 mg/kg telmisartan daily intragastrically. Sub group IIC: diabetic rats received 10mg/kg gliclazide daily intragastrically. Diabetes was induced by intraperitoneal injection of 55 mg/kg STZ for 8 weeks evidenced by significant increase in serum glucose, HBA(1c) and decreased Hb levels.
Results:
Diabetic rats showed a significant increase in tissue TBARs and a significant decrease in tissue (GSH) and (SOD) enzymes. Telmisartan or Gliclazide in diabetic rats produced a beneficial effect on serum glucose, Hb, HBA(1c) and restored tissue GSH and SOD with a fall in tissues TBARS.
Conclusion:
Telmisartan might be proved useful in the treatment of diabetes and its complications, as Gliclazide is restricted by its secondary failure rate and side effects.
Insights
Telmisartan, an angiotensin receptor antagonist, demonstrated antidiabetic and antioxidant effects in streptozotocin-induced diabetic rats. It improved glycemic control and restored tissue antioxidant enzymes, suggesting potential for treating diabetes and its complications.
Area of Science:
- Endocrinology
- Pharmacology
- Diabetology
Background:
- Oxidative stress contributes to diabetic nephropathy and neuropathy.
- Angiotensin II plays a role in diabetic complications.
- Angiotensin receptor antagonists may offer protective effects similar to ACE inhibitors.
Purpose of the Study:
- To investigate the antidiabetic and tissue antioxidant effects of Telmisartan.
- To compare Telmisartan's effects with Gliclazide in a rat model of diabetes.
Main Methods:
- 40 rats were divided into control, diabetic, and treatment groups.
- Diabetes was induced using streptozotocin (STZ).
- Groups received distilled water, STZ, STZ + Telmisartan, or STZ + Gliclazide.
Main Results:
- Diabetic rats exhibited increased TBARs and decreased GSH and SOD.
- Telmisartan and Gliclazide improved serum glucose, Hb, and HbA1c.
- Both treatments restored tissue GSH and SOD levels while reducing TBARs.
Conclusions:
- Telmisartan shows potential as an antidiabetic agent.
- Its antioxidant properties may help manage diabetes complications.
- Telmisartan offers an alternative to Gliclazide, considering Gliclazide's limitations.
