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Updated: Jun 2, 2026

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
Published on: June 12, 2014
In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica
Catalina Leos-Rivas1, M Julia Verde-Star, Lidia Osuna Torres
1Faculty of Biological Sciences, Universidad Autonoma de Nuevo Leon, Pedro de Alba y Manuel L. Barragan, Ciudad Universitaria, San Nicolas de los Garza, Nuevo Leon, Mexico.
Abstract:
Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC₅₀ of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
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