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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
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A Rat Model of Compound Acne
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Published on: November 1, 2024

Acne vulgaris.

Sarah Purdy1, David de Berker

  • 1University of Bristol, Bristol, UK.

BMJ Clinical Evidence
|April 12, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates topical and oral acne vulgaris treatments. It found 69 studies on interventions like adapalene, isotretinoin, and tetracyclines, assessing their effectiveness and safety for acne patients.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Evidence-based Medicine

Background:

  • Acne vulgaris impacts over 80% of teenagers and persists into adulthood.
  • Acne lesions range from comedones to inflammatory papules, pustules, nodules, and cysts.
  • Severe acne can lead to scarring and significant psychological distress.

Purpose of the Study:

  • To systematically review the effects of topical and oral treatments for acne vulgaris.
  • To evaluate the effectiveness and safety of various acne interventions.

Main Methods:

  • Systematic review of medical literature up to February 2010.
  • Inclusion of 69 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • GRADE evaluation of evidence quality for interventions.

Main Results:

  • Identified numerous topical treatments including adapalene, azelaic acid, benzoyl peroxide, clindamycin, erythromycin, isotretinoin, tetracycline, and tretinoin.
  • Identified oral treatments such as doxycycline, isotretinoin, lymecycline, minocycline, oxytetracycline, and tetracycline.
  • Assessed the effectiveness and safety of these interventions based on GRADE criteria.

Conclusions:

  • The review synthesizes evidence on the effectiveness and safety of key topical and oral acne treatments.
  • Provides a comprehensive overview for clinicians managing acne vulgaris.
  • Highlights the range of available therapeutic options for different acne severities.