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Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
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Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

Amoebic dysentery.

Nicole M Mackey-Lawrence1, William Arthur Petri

  • 1University of Virginia, Charlottesville, USA.

BMJ Clinical Evidence
|April 12, 2011
PubMed
Summary
This summary is machine-generated.

This review examines drug treatments for amoebic dysentery, a parasitic infection common in areas with poor sanitation. It summarizes the effectiveness and safety of various medications used to combat this disease.

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Area of Science:

  • Infectious Diseases
  • Parasitology
  • Public Health

Background:

  • Amoebic dysentery is a significant health concern caused by Entamoeba histolytica.
  • Transmission occurs in regions with inadequate sanitation, leading to contaminated food and water.
  • Up to 40% of diarrhea cases in endemic areas may be attributed to amoebic dysentery.

Purpose of the Study:

  • To systematically review the clinical effectiveness and safety of drug treatments for amoebic dysentery.
  • To answer the clinical question regarding the effects of various interventions in endemic regions.

Main Methods:

  • Conducted a systematic literature review up to April 2010.
  • Searched major databases including Medline, Embase, and The Cochrane Library.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified 6 systematic reviews, RCTs, or observational studies meeting inclusion criteria.
  • Performed a GRADE evaluation to assess the quality of evidence for interventions.

Conclusions:

  • Presents information on the effectiveness and safety of 9 key interventions.
  • Includes diiodohydroxyquinoline (iodoquinol), diloxanide, emetine, metronidazole, nitazoxanide, ornidazole, paromomycin, secnidazole, and tinidazole.