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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Methods to predict and lower the risk of prostate cancer

Barbara Ercole1, Dipen J Parekh

  • 1Department of Urology, University of Texas Health Science Center, San Antonio, USA.

Thescientificworldjournal
|April 12, 2011
PubMed

Insights

Chemoprevention aims to prevent prostate cancer (PCa). 5 alpha-reductase inhibitors show risk reduction, but selenium and vitamin E do not decrease PCa risk.

Area of Science:

  • Oncology
  • Preventive Medicine
  • Urology

Background:

  • Prostate cancer (PCa) chemoprevention is of significant interest to clinicians and patients.
  • The primary objective of chemoprevention is to inhibit the malignant transformation of prostate cells.

Purpose of the Study:

  • To review the efficacy of various chemopreventive agents for prostate cancer.
  • To summarize findings from key clinical trials investigating PCa risk reduction.

Main Methods:

  • Review of major clinical trials, including the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial.
  • Analysis of results from the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Main Results:

  • 5 alpha-reductase inhibitors demonstrated a reduction in prostate cancer risk in the PCPT and REDUCE trials.
  • The SELECT trial concluded that selenium and vitamin E do not decrease the risk of prostate cancer.

Conclusions:

  • 5 alpha-reductase inhibitors are effective chemopreventive agents for prostate cancer.
  • Selenium and vitamin E supplementation do not offer a protective effect against prostate cancer.

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