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Tapping an unexploited repository: Carnoy's fixed cell pellets for proteomic biomarker research in leukemia
Ferdinand Von Eggeling1, Annett Bleul, Ivan F Loncarevic
1Core Unit Chip Application, Institute of Human Genetics and Anthropology, Klinikum der FSU Jena, D-07740 Jena, Germany. fegg@mti.uni-jena.de.
Abstract:
For chromosomal analysis in tumor genetics, cells from blood and bone marrow are prepared and preserved virtually indefinitely in Carnoy's fixative (methanol/acetic acid). Numerous samples are stored unvalued in hospitals and institutes worldwide. We developed a method to analyze proteins from even a small amount of these cells by mass spectrometry using affinity chromatographic surfaces (SELDI), and demonstrated the application of proteomic biomarker research in cases of acute myeloid leukemia.
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