[Clinico-immunologic characteristics of appendicitis in children]

Inflammation of the appendix is primarily a local process with the development of localized subcompensation of immunogenesis in simple appendicitis. Decompensation of immunogenesis and a destructive process develop in progressive insufficiency of immune reactions, in immune reactions of considerable intensity the inflammation is arrested spontaneously, but atrophy of lymphoid tissue remains as a consequence. Frequent (48.7%) recurrent inflammation is attended by a more severe clinical course and rapid development of complications, owing to which appendectomy is recommended in simple appendicitis. The authors revealed changes of the general resistance of the organism, which were manifested by activation of leukocyte phagocytic activity and reduction of their content of cation proteins and by increase of the level of circulating immune complexes in the blood.