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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: Jun 2, 2026

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

Tumor microenvironment and progression.

Harold F Dvorak1, Valerie M Weaver, Thea D Tlsty

  • 1Department of Pathology, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. hdvorak@bidmc.harvard.edu

Journal of Surgical Oncology
|April 12, 2011
PubMed
Summary
This summary is machine-generated.

Tumor blood vessels are diverse and targeted by vascular endothelial growth factor-A (VEGF-A). Targeting these vessels offers a therapeutic strategy for cancers like breast cancer, influencing microenvironment and homeostasis.

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Last Updated: Jun 2, 2026

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression
08:26

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Published on: February 17, 2012

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

Area of Science:

  • Oncology
  • Vascular Biology
  • Cancer Therapeutics

Background:

  • Tumor vasculature is heterogeneous, comprising at least six distinct types.
  • Vascular endothelial growth factor-A (VEGF-A) is a primary inducer of tumor blood vessels.
  • Breast cancer involves microenvironmental changes affecting tensional homeostasis and arises from genetic/epigenetic alterations.

Purpose of the Study:

  • To highlight the therapeutic potential of targeting heterogeneous tumor blood vessels.
  • To underscore the role of VEGF-A in tumor angiogenesis and its implications in cancer.
  • To explore the origins of tumor blood vessel pericytes and VEGF's regulatory functions.

Main Methods:

  • Review of existing literature on tumor vasculature and VEGF-A.
  • Analysis of the role of microenvironmental factors in breast cancer.
  • Investigation into the cellular origins of tumor pericytes.

Main Results:

  • Tumor blood vessels are highly diverse and primarily induced by VEGF-A.
  • These vessels represent a viable therapeutic target.
  • VEGF-A also acts as a negative regulator of glioblastoma cell invasion.

Conclusions:

  • Targeting the diverse tumor vasculature, induced by VEGF-A, is a promising therapeutic strategy.
  • Understanding tumor microenvironment alterations and pericyte origins is crucial for cancer treatment.
  • VEGF-A's multifaceted role warrants further investigation in various cancers.