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Related Experiment Video

Updated: Jun 2, 2026

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Using a Cyclic Ion Mobility Spectrometer for Tandem Ion Mobility Experiments

Published on: January 20, 2022

Achieving 0.2% relative expanded uncertainty in ion chromatography analysis using a high-performance methodology.

Ryan G Brennan¹, Therese A Butler, Michael R Winchester

¹Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA.

Analytical Chemistry

|April 13, 2011

Summary

A high-performance technique originally for ICP-OES was adapted for ion chromatography (IC), achieving very low uncertainty in anion analyses. This method, validated with NIST standards, demonstrates high precision for critical chemical measurements.

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Area of Science:

Analytical Chemistry
Chromatography
Spectrometry

Background:

Traditional analytical methods often face limitations in achieving extremely low measurement uncertainty.
High-performance techniques developed for one analytical field may offer significant advantages when translated to others.

Purpose of the Study:

To adapt a high-performance (HP) technique from ICP-OES to ion chromatography (IC).
To demonstrate the capability of HP-IC for highly accurate anion analyses.
To report uncertainty values for NIST Standard Reference Materials using the developed HP-IC method.

Main Methods:

Translation of a high-performance (HP) technique from inductively coupled plasma optical emission spectrometry (ICP-OES) to ion chromatography (IC).
Analysis of National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) from the SRM 3180 series (anion standard solutions).
Utilized strong correlation between analyte and internal standard anion peak characteristics (heights or areas).
Implemented a unique drift-correction approach.

Main Results:

Successful adaptation of HP-IC methodology for ultra-low uncertainty analyses.
Relative expanded uncertainty (95% confidence) for NIST SRM anion solutions ranged from 0.087% to 0.27%.
Average relative expanded uncertainty achieved was 0.18%.

Conclusions:

The HP-IC methodology enables highly precise and accurate anion analyses.
The combination of internal standardization and drift correction is crucial for achieving sub-0.2% uncertainty.
This HP-IC approach offers a significant advancement for trace anion quantification.