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Related Experiment Video

Updated: Jun 2, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Primary teeth show less protecting factors against root resorption.

Mabel M R Cordeiro¹, Bianca Z Santos, Jessie F Reyes-Carmona

¹Department of Morphological Sciences, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil. mcordeiro@ccb.ufsc.br

International Journal of Paediatric Dentistry

|April 13, 2011

Summary

Primary teeth exhibit less protection against root resorption due to fewer ECRM clusters and lower OPG expression compared to permanent teeth. This difference in the periodontal ligament (PDL) influences resorption regulation.

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Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

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Published on: April 26, 2024

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Published on: August 22, 2022

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Published on: April 26, 2024

Area of Science:

Cell Biology
Dental Research
Immunohistochemistry

Background:

Physiological root resorption is a key difference between primary and permanent teeth.
Understanding resorption regulation is crucial for developing therapies to control it.

Purpose of the Study:

To investigate the distribution of ECRM (Enamel matrix-derived proteins) and expression of CK14, OPG, TRAP, and COX-2 in the periodontal ligament (PDL) of human primary and permanent teeth.
To compare these markers in teeth undergoing physiological or pathological root resorption.

Main Methods:

Immunohistochemical analysis was performed on eight primary teeth and four permanent teeth.
Specific markers analyzed included CK14, TRAP, COX-2, and OPG.

Main Results:

Primary teeth PDL had fewer ECRM clusters and higher CK14 immunoreactivity than permanent teeth.
Howship's lacunae, TRAP-positive cells, and increased COX-2 expression were observed only in primary teeth.
OPG expression was lower in primary teeth PDL, particularly in resorptive areas, and higher in permanent teeth PDL.

Conclusions:

Primary teeth PDL show reduced ECRM clusters and lower OPG expression, suggesting less inherent protection against root resorption.
These findings highlight potential differences in the mechanisms regulating root resorption between primary and permanent dentition.