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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Updated: Jun 2, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

Cell therapy for ischaemic stroke.

D C Hess1, W D Hill

  • 1Department of Neurology and Cell Biology and Anatomy, Medical College of Georgia, Augusta, 30912, USA. dhess@mcg.edu

Cell Proliferation
|April 13, 2011
PubMed
Summary
This summary is machine-generated.

Restorative cell therapy shows promise for stroke recovery by targeting brain remodelling. Further research and well-designed clinical trials are crucial for advancing this promising stroke treatment.

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A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
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Published on: June 22, 2022

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Last Updated: Jun 2, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
14:53

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Translational Medicine

Background:

  • Acute neuroprotection strategies for stroke have faced significant challenges and numerous failures.
  • There is a growing shift towards restorative therapies focused on brain remodelling post-stroke.

Purpose of the Study:

  • To review the current state and future directions of cell therapy for stroke.
  • To highlight the potential of cell transplantation in improving functional outcomes and addressing the unmet clinical need in stroke recovery.

Main Methods:

  • Review of pre-clinical evidence from animal models of stroke.
  • Analysis of the current landscape of ongoing and planned clinical trials.
  • Discussion of the mechanistic questions and challenges in cell therapy for stroke.

Main Results:

  • Pre-clinical studies consistently demonstrate improved functional outcomes with cell therapy in animal models.
  • Clinical trials are emerging, indicating a transition from basic research to clinical application.
  • Key questions regarding the mechanisms of action of transplanted cells persist.

Conclusions:

  • Cell therapy presents a promising avenue for stroke recovery, moving beyond acute neuroprotection.
  • Continued rigorous pre-clinical investigation and carefully designed clinical trials are essential for therapeutic advancement.
  • Successful implementation of cell therapy could address a significant unmet need in stroke patient care.