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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

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Interstrand dipole-dipole interactions can stabilize the collagen triple helix

Matthew D Shoulders1, Ronald T Raines

  • 1Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

The Journal of Biological Chemistry
|April 13, 2011
PubMed
Summary

Collagen stability is enhanced by specific proline derivatives, particularly (2S,4R)-4-hydroxyproline (Hyp), in the Xaa position. Interstrand dipole-dipole interactions explain the hyperstability of GlyHypHyp collagen sequences.

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