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Related Experiment Video

Updated: Jun 2, 2026

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition

Published on: September 3, 2016

Antibiotics, acne, and Staphylococcus aureus colonization.

Matthew Fanelli¹, Eli Kupperman, Ebbing Lautenbach

¹Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Archives of Dermatology

|April 13, 2011

Summary

This summary is machine-generated.

Long-term tetracycline antibiotic use for acne reduced Staphylococcus aureus colonization without increasing resistance. This challenges conventional thinking on antimicrobial agent use in acne treatment.

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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

Area of Science:

Dermatology
Infectious Diseases
Microbiology

Background:

Staphylococcus aureus colonization is common in patients with acne.
The impact of antibiotic therapy on S. aureus colonization and resistance patterns in acne patients is not fully understood.

Purpose of the Study:

To determine the frequency of S. aureus colonization in acne patients.
To compare S. aureus susceptibility patterns between antibiotic users and non-users.

Main Methods:

Cross-sectional survey study conducted in a dermatology outpatient setting.
Included 83 patients undergoing treatment for acne.
Assessed S. aureus colonization in the nose or throat.

Main Results:

43% of participants (36/83) were colonized with S. aureus.
Methicillin-resistant S. aureus (MRSA) was found in 6% of colonized patients.
S. aureus isolates showed high resistance to clindamycin (40%) and erythromycin (44%), but low resistance (<10%) to tetracycline antibiotics.

Conclusions:

Prolonged use of tetracycline antibiotics for acne decreased S. aureus colonization.
Tetracycline use did not increase resistance to these antibiotics, contrary to general concerns about antimicrobial agents.
Findings suggest tetracyclines may have a beneficial role in managing S. aureus colonization in acne patients.