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Updated: Jun 2, 2026

Recombinant Retroviral Production and Infection of B Cells

Recombinant Retroviral Production and Infection of B Cells

Published on: February 18, 2011

Reversing B cell aging.

Ramit Mehr¹, Doron Melamed

¹The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.

|April 13, 2011

Summary

This summary is machine-generated.

Aging causes poor antibody responses in the elderly due to changes in B cells. Restoring B cell balance can reverse this age-related decline in immune function.

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The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

The Isolation, Differentiation, and Quantification of Human Antibody-secreting B Cells from Blood: ELISpot as a Functional Readout of Humoral Immunity

Published on: December 14, 2016

Area of Science:

Immunology
Gerontology
Cellular Biology

Background:

Age-related changes in B cell populations contribute to diminished antibody responses in older adults.
The underlying mechanisms driving these B cell alterations and immune decline are not fully understood.

Purpose of the Study:

To explore the role of B cell homeostasis in age-related immunosenescence.
To discuss potential strategies for rejuvenating the aging B cell compartment.

Main Methods:

Analysis of age-related changes in B cell composition.
Investigating the impact of B cell depletion on immune aging.
Discussion of homeostatic mechanisms influencing B cell longevity and function.

Main Results:

Accumulation of long-lived B cells with aging contributes to altered B cell composition.
Depletion of B cells can reverse age-related changes in the B cell lineage, improving immune homeostasis.
These findings suggest a link between B cell accumulation and immunosenescence.

Conclusions:

Homeostatic pressures, particularly the accumulation of long-lived B cells, are key drivers of B lineage immunosenescence.
Modulating B cell homeostasis offers a promising therapeutic avenue for rejuvenating immune function in the elderly.