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Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Gastrotomy closure with a new tissue anchoring device: a porcine survival study
Carlos Guarner-Argente1, Henry Córdova, Graciela Martínez-Pallí
1Endoscopy Unit, Hospital Clínic, CIBERehd, Barcelona 08026, Spain.
Aim:
To evaluate the feasibility, reproducibility and efficacy of a new tissue anchoring device in a porcine survival model.
Methods:
Gastrotomies were performed using a needle-knife and balloon dilator in 10 female Yorkshire pigs weighing 30-35 kg. Gastric closure was attempted using a new tissue anchoring device. The tightness of the closure was confirmed by means of air insufflation and the ability to maintain gastric distension with stability in peritoneal pressure measured with a Veress needle. All animals were monitored daily for signs of peritonitis and sepsis over 14 d. During necropsy, the peritoneal cavity and the gastric access site were examined.
Results:
Transgastric access, closure and 14 d survival was achieved in all pigs. The mean closure time was 18.1 ± 19.2 min and a mean of 2.1 ± 1 devices were used. Supplementary clips were necessary in 2 cases. The closure time was progressively reduced (24.8 ± 13.9 min in the first 5 pigs vs 11.4 ± 5.9 min in the last 5, P = NS). At necropsy, the gastric access site was correctly closed in all cases with all brace-bars present. One device was misplaced in the mesocolon. Minimal adhesions were observed in 3 pigs and signs of mild peritonitis and adhesions in one.
Conclusions:
The use of this new tissue anchoring device in porcine stomachs is feasible, reproducible and effective and requires a short learning curve.
