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Related Experiment Video

Updated: Jun 2, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.

William R Swindell1, Andrew Johnston, Steve Carbajal

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. wswindell@genetics.med.harvard.edu

Plos One
|April 13, 2011
PubMed
Summary

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Genetic liability to psoriasis predicts severe disease outcomes.

Genome medicine·2025

Developing accurate mouse models for psoriasis is crucial for understanding disease mechanisms and treatments. This study compared gene expression in five mouse models to human psoriasis, finding each model offers unique insights despite variations in immune response genes.

Area of Science:

  • Dermatology
  • Immunology
  • Genomics

Background:

  • Psoriasis is a complex human skin disease.
  • Existing mouse models for psoriasis lack comprehensive validation.
  • Standardized criteria for evaluating psoriasis mouse models are needed.

Purpose of the Study:

  • To compare gene expression profiles of five distinct psoriasis mouse models with human psoriatic skin lesions.
  • To evaluate the utility of these models for studying psoriasis pathomechanisms and therapeutic development.
  • To establish an objective method for assessing the validity of psoriasis mouse models.

Main Methods:

  • Whole-genome transcriptional profiling was employed.
  • Gene expression data from human psoriatic lesions were compared to five mouse models: K5-Tie2, imiquimod, K14-AREG, K5-Stat3C, and K5-TGFbeta1.

Related Experiment Videos

Last Updated: Jun 2, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

  • Statistical analysis was used to determine similarities and differences in gene expression patterns.

    • Main Results:

    • All five mouse models showed statistically significant similarities to human psoriasis gene expression profiles.
    • Models demonstrated strong concordance with human disease in genes related to epidermal development and keratinization.
    • Immune and inflammation-associated gene expression varied more significantly across models compared to human psoriasis.

    Conclusions:

    • The five evaluated mouse models are valuable research tools for psoriasis studies, each offering unique strengths and weaknesses.
    • Each model exhibits specific areas of convergence and divergence when compared to human psoriasis.
    • The employed transcriptional profiling approach provides a quantitative method for evaluating future psoriasis mouse models.