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Target binding influences permeability in aptamer-polyelectrolyte microcapsules.

Yasir Sultan1, Maria C DeRosa

  • 1Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada.

Small (Weinheim an Der Bergstrasse, Germany)
|April 13, 2011
PubMed
Summary
This summary is machine-generated.

Aptamer-polyelectrolyte microcapsules were created using layer-by-layer deposition. These smart microcapsules show potential for triggered delivery and microreactors, demonstrating specific target recognition and controlled permeability.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Aptamers are oligonucleotides that can bind to specific targets.
  • Polyelectrolytes are polymers with charged groups.
  • Microcapsules offer potential for controlled substance delivery and reactions.

Purpose of the Study:

  • To prepare aptamer-polyelectrolyte microcapsules for triggered delivery and microreactor applications.
  • To investigate the structural integrity and target recognition capabilities of these microcapsules.
  • To assess the permeability characteristics of the aptamer-functionalized microcapsules.

Main Methods:

  • Layer-by-layer (LbL) film deposition using a sacrificial CaCO(3) core.
  • Scanning electron microscopy (SEM) and confocal microscopy for structural analysis.
  • Colocalization studies and fluorescence recovery after photobleaching (FRAP) for permeability and target recognition assessment.

Main Results:

  • Spherical CaCO(3) cores and LbL-aptamer microcapsules were successfully fabricated.
  • Aptamers demonstrated specific recognition of their target (sulforhodamine B) in the presence of K+ ions.
  • Aptamer-polyelectrolyte microcapsules exhibited significantly different permeability compared to control microcapsules.

Conclusions:

  • Aptamer-polyelectrolyte microcapsules are viable for creating 'smart' responsive materials.
  • These microcapsules show promise for applications in catalysis and controlled release systems.
  • The specific recognition and permeability control highlight the potential of aptamer-based nanostructures.