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Published on: May 2, 2025
Glycemic status, lipid profile and proteinuria in diabetic nephropathy
1Department of Biochemistry, BP Koirala Institute of Health Sciences, Dharan, Nepal. punamjha@yahoo.com
Introduction:
Diabetic nephropathy is one of the major complications of Diabetes Mellitus characterized by persistent albuminuria, elevated arterial blood pressure, a relentless decline in glomerular filtration rate (GFR) and a high risk of cardiovascular morbidity and mortality.
Methods:
In this study, urinary micro-albumin estimation was done in 177 diabetic patients. This study aims to ascertain association of glycemic status, lipid profile and proteinuria in Type 2 Diabetes Mellitus with nephropathy.
Results:
Among 177 patients, 26 had frank proteinuria, 79 had micro-albuminuria and 72 were without proteinuria. Increased frequency of proteinuria was seen in male than female. Micro-albuminuria and frank proteinuria was seen more in older age group. The multiple comparisons showed the significantly increased levels of urea, creatinine, fasting blood glucose in micro-albuminuria and overt proteinuria patients in comparison to without proteinuria. Glycated hemoglobin level was increased with the increasing age group particularly in overt proteinuric patients.
Conclusions:
The glycemic control, monitoring of lipid profile and early urinary protein estimation with better management may delay diabetic nephropathy or its further complications in diabetes mellitus.
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